SIDE-EFFECTS
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using esomeprazole and contact your doctor right away if you experience any of the following side effects:
- dizziness, confusion;
- fast or uneven heart rate;
- jerking muscle movements;
- jittery feeling;
- diarrhea that is watery or bloody;
- muscle cramps, muscle weakness or limp feeling;
- cough or choking feeling; or
- seizure (convulsions).
Less serious side effects may include:
- headache, drowsiness;
- mild diarrhea;
- nausea, stomach pain, gas, constipation; or
- a dry mouth.
Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures).
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool. Rarely, proton pump inhibitors (such as esomeprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, kidney problems (such as change in the amount of urine). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Some symptoms may well be signs of a more serious condition. Get medical help right away if you have: heartburn with light-headedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss.
SAFETY
Before taking esomeprazole, tell your doctor or pharmacist if you are allergic to it - or to similar drugs (such as lansoprazole, omeprazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.
Nexium (esomeprazole is a competitive inhibitor of the enzyme CYP2C19, so other drugs that rely on this enzyme might be affected by its use. For instance, diazepam and warfarin are broken down by CYP2C19. Levels of these drugs in the body might rise if taken alongside a proton pump inhibitor.
Other drugs, such as clopidogrel (Plavix) depend on CYP2C19 to be converted into their active form; their effect will therefore be reduced if taken alongside esomeprazole.
A change in stomach acidity also changes the way certain drugs are absorbed. Some drugs require an acidic environment to be absorbed, such as ketoconazole or atazanavir. Others, including erythromycin, are degraded by stomach acid, so in more alkaline situations they will be absorbed in greater quantities.
DISCLAIMERS:
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