Is A Prescription Required to Have Motilium?

A Prescription is required to purchase Motilium from our licensed Canadian pharmacy online.

What Is Motilium Used For?

Motilium is an anti-emetic drug which is used for the treatment of nausea and vomiting. It is also used to treat discomfort caused by a slow moving stomach known as gastroparesis.

What Is Gastroparesis?

It is a stomach disease caused by a slow moving stomach with symptoms such as not being able to finish a meal, a feeling of being “too full” or bloated after a meal, loss of appetite, feeling sick, vomiting or belching without any relief.

What Does Motilium Do?

The medication Motilium (domperidone) belongs to the class of anti-emetics. It is a prokinetic medicine and works by blocking the action of a chemical messenger in brain which is responsible for nausea and vomiting. It also increases the contractions of the stomach and intestines, thus allowing food to move more easily through stomach.

Is Domperidone Used for Motion Sickness?

The medication domperidone can be used to prevent and treat nausea and vomiting that are the most common signs and symptoms of motion sickness.

Can Motilium Increase Breast Milk?

Various long-term studies with Motilium have shown side effects related to increase in serum prolactin that can lead to increased breast secretion and lactation. Please check here to see if domperidone is appropriate used for increasing breast milk supply.

What Is the Generic Form of Motilium?

The generic form of Motilium is domperidone and it comes from Canada.

How Is Motilium Supplied and Stored?

We primarily stock generic Motilium from Canada and it is manufactured by Pharmaris Inc. We also supply different versions of Domperidone from Canada and it comes by various manufacturers such as Apotex, Teva, Marcon, or Pharma Science. The generic version of Motilium (domperidone) is available in 10 mg dosage form in packing of 100, 500, and 1000 tablets in bottles.

The medication should be stored in a cool dry place where the temperature is below 30°C. Keep the tablets in the pack until it is time to take them. Do not store Motilium tablets in the bathroom or near a sink, in car or on windowsills. It should be kept out of sight and reach of children.

What Is the Cost of Generic Motilium?

Our verified online pharmacy is pleased to offer you the generic Motilium 10 mg at an unbeatable price of $175 for a supply of 1000 tablets, which is $0.18 per unit. Shop safely and save more on Motilium prescription from Canadawidepharmacy.com.

How Many Motilium Can You Take In A Day?

The usual adult dose of Motilium for adults is one tablet 3 times a day. The medicine should not be used for more than 7 days without consulting your doctor. Do not take more than 3 tablets per day.

How Do You Take Motilium?

Take the medication exactly as prescribed by your doctor. If you do not understand the instructions on the bottle, ask your doctor or pharmacist for help. Motilium is to be taken 15 to 30 minutes before meals, preferably at bedtime. If you forget to take a dose, leave out that dose and take the next one when it is due.

How Long Did It Take For Domperidone To Work For You?

Domperidone can take 30 to 60 minutes to provide relief from nausea and its effect lasts for about 6 to 8 hours.

Can You Drive While Taking Motilium?

Motilium use can lead to dizziness and drowsiness. Do not drive or operate heavy machinery, until you know how Motilium affects you.

How is Motilium Metabolized in Body?

The drug is metabolized in liver extensively and has a half-life of 7 to 9 hours.

What Are The Possible Side Effects of Motilium?

Like all other medications, Motilium can also cause side effects. Most common side effects include headache, troubled sleeping, nervousness, depression, dizziness, fatigue, irritability, drowsiness, fits or seizures, dryness in mouth, thirst, regurgitation, diarrhea, constipation, nausea, heartburn, appetite changes, itchiness or rashes on skin, itchy eyes, crusty eyelids with discharge, mouth ulcers or cold sores. These side effects are generally mild and temporary. Tell your doctor if these side effects continue. Other side effects include uncontrollable movements in face, arms or legs, excessive trembling, muscle stiffness, muscle spasm, irregular or no menstrual periods, unusual secretion of breast milk, decrease in sex drive in men or women, breast enlargement or tenderness in men and women. These side effects reverse, if the medication is discontinued. It is important to stop taking Motilium and inform your health care professional immediately if you experience any of the following side effects:

• Irregular or fast heartbeats
• Frequent urination
• Pain while urinating
• Swelling of hands, ankles or feet
• Allergic reaction to Motilium with symptoms such as rashes, itching, shortness of breath, swelling of face, lips, mouth, tongue or throat, difficulty in swallowing or breathing

Motilium has been associated with sudden risk of unusual heartbeat or heart failure, especially in patients of 60 years of age or above or in patients who take more than 3 tablets daily. Talk to your doctor if you have any pre-existing problems. Stop Motilium treatment and contact your doctor or pharmacist immediately if you notice any signs of unusual heartbeat.

When Should You Not Take Motilium?

Do not take Motilium if you:

• Have any allergy to domperidone or any other ingredients in Motilium
• Have liver disease
• Have tumor of pituitary gland called prolactinoma
• Increased stomach or bowel contractions
• Bleeding, blockage or puncture in your gastrointestinal tract
• Have heart problems or abnormal heartbeat
• Are taking any other medicine which contain ketoconazole, voriconazole, itraconazole, posaconazole that are used to treat fungal infections
• Are taking medicines that contain ritonavir or saquinavir which are used to treat HIV
• Are taking medicines which contain telaprevir which is used to treat hepatitis C
• Are taking antibiotics that contain erythromycin, clarithromycin or telithromycin

What Should You Tell Your Doctor Before taking Motilium?

Before you start taking Motilium, be sure to tell your doctor if you:

• Are pregnant or planning a pregnancy
• Are breastfeeding or plan to do so
• Have heart problems
• Have kidney diseases
• Have or had breast cancer
• Are unable to digest lactose (a sugar found in milk and milk products)
• Motilium should not be used in children

What Medicines Can Interact With Motilium?

It is important to tell your health care professional about all other medicines that you have taken recently including any kind of supplements and non-prescription drugs. Medicines which interact with Motilium include:

• Itraconazole, ketoconazole, posaconazole, or voriconazole (anti-fungal medications)
• Eryrthromycin, clarithromycin, or telithromycin (antibiotics)
• Amiodarone (a heart medicine used to treat fast heart rate)
• Ritonavir or saquinavir (used to treat HIV/AIDS)
• Teleprevir (used to treat hepatitis C)
• Anticholinergic drugs such as medicines used for treatment of allergy, asthma, incontinence, gastrointestinal cramps, muscular spasm, depression or sleep disorders such as diphenhydramine
• Dopaminergic agonists (used for treatment of Parkinson’s disease or digestive disorders)
• Medications used for treatment of high blood pressure or chest pain such as verapamil, diltiazem
• Aprepitant used to treat nausea, vomiting
• Antidepressant called nefazodone
• Antacids. Do not take antacids within 2 hours of taking Motilium, because sufficient stomach acid is required for compelet absorption of Motilium

Where Can I Buy Motilium Online?

If prescribed by your health care professional, Motilium can be bought directly from Canadian Online Pharmacy. You will not have to wait to start your therapy due to the swift shipping service provided by us.

How Is Motilium Delivered?

The standard delivery fee is $10.00. The orders are usually shipped in 2-3 working days after the processing of the order. The medication package is delivered by regular mail within 10-14 business days after it has been shipped. For further information and aid, you can contact our Customer Service at 604-581-4000 or email us at customerservice@canadawidepharmacy.com.

References:

1. http://www.janssen.com/australia/sites/www_janssen_com_australia/files/prod_files/live/motilium_pi.pdf
2. http://www.janssen.com/australia/sites/www_janssen_com_australia/files/prod_files/live/motilium_cmi.pdf

DESCRIPTION

Motilium (Domperidone) is an Rx medication that is used to treat slowed movement in the gastrointestinal tract associated with diabetes and gastritis (inflammation of the stomach lining). For these people, domperidone (dom-PAIR-eh-doan) improves symptoms of nausea (feeling sick), vomiting (being sick), bloating, and the feeling of fullness.

Domperidone belongs to the group of medications called dopamine antagonists and is also used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson's disease. It works to improve symptoms by helping the stomach to empty more quickly and to reduce nausea.

Domperidone works primarily by blocking dopamine receptors found in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and so prevents reflux (regurgitation of the stomach contents back into the food pipe).

Domperidone also blocks dopamine receptors found in an area of the brain known as the chemoreceptor trigger zone (CTZ). The CTZ is activated by nerve messages from the stomach when an irritant is present. It is also activated directly by agents circulating in the blood, for example chemotherapy medicines. Once activated, it sends messages to another area of the brain, the vomiting centre, which in turn sends messages to the gut, thereby causing the vomiting reflex. Blocking the dopamine receptors in the CTZ prevents nausea messages from being sent to the vomiting centre which, in turn, reduces the sensation of nausea and prevents vomiting.

PACKAGING

Generic Motilium (Domperidone) comes from Canada and is manufactured by Marcon Pharmaceuticals. Brand Motilium is not available. The Generic Equivalent of Motilium medication is available in 10 mg containing quantities of: 100, 200, 500, 720 and 1000 tablets packed in bottles.

Please be advised, that Generic drugs are fully licenced and approved copies of brand-name drugs that have the same dosage, intended use, effects, side effects, route of administration, risks, safety, and strength as the original drug. In other words, their pharmacological effects are the same as those of their brand-name counterparts. We are happy (whenever we are able) to provide a choice, especially as Generic versions are generally cheaper, thereby making them more affordable and accessible! In this instance, we are unable to offer the brand-name version.

Please store this medication at room temperature, protect it from light and moisture, and keep it out of the sight and reach of children.

Please do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. These measures will help to protect the (our) environment.

Please note that the manufacturing country and the manufacturer may vary depending on the availability.

DELIVERY

The standard shipping fee is a flat rate of $10.00. Orders are normally dispatched in 2-3 working days after the order is processed. Your package will be delivered by regular mail in 10-14 business days after it is shipped out.

SIDE-EFFECTS

Please remember that, just because a side effect is listed here does not mean that all people using this medicine will experience any side effect – we are all different.

Most common side effects include: Dry mouth.

Less common side effects include:

• Sleepiness.
• Headache.
• Anxiety.
• Feeling weak.
• Loss of sex drive.
• Diarrhoea.
• Rash.
• Itching.
• Breast pain or tenderness.
• Production of breast milk.

Rare possible side effects:

• Itchy nettle-type rash (hives or urticaria).
• Swelling of the face, tongue or throat (angioedema).
• Agitation.
• Nervousness.
• Convulsions.
• Abnormal or uncontrolled movements of the hands, legs, face, eyes, neck or tongue, for example tremor, twitching or stiffness (extrapyramidal effects). Consult a doctor straight away if you notice any symptoms like this.
• Increased level of prolactin (milk producing hormone) in the blood (hyperprolactinaemia). Sometimes this can lead to symptoms such as enlargement of breasts in men (gynaecomastia) or stopping of menstrual periods in women.
• Difficulty passing urine.
• Abnormal heart rhythm, seen as a 'prolonged QT
interval' on a heart monitoring trace (ECG).
• Irregular heartbeat - arrhythmia
• Abnormal liver function.

Talk to your doctor or pharmacist if you want any more information about the possible side effects of this medicine. Please be sure to speak with your doctor or pharmacist if you are concerned about any side-effects that you may have – especially if they are persistent.

SAFETY

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Do not take domperidone if you:

• have heart disease such as heart failure, or a very slow or irregular heartbeat,
• have an abnormal heart rhythm seen on a heart monitoring trace (ECG) as a "prolonged QT interval" and people taking other medicines that can cause this problem - see below under ‘’Can Other Medicines Affect Motilium?’’,
• are allergic to domperidone or any ingredients of the medication, which are - The active substance is domperidone maleate,
10mg per tablet. The other ingredients are microcrystalline cellulose, lactose monohydrate, maize starch, povidone K30, sodium,lauryl sulphate, silica colloidal anhydrous, magnesium stearate.
• are taking the medication ketoconazole,
• are taking medications which cause QT prolongation,
• have bleeding in the stomach or intestines,
• have a blockage in the stomach or intestines,
• have breaks in the lining of the stomach or intestines,
• have a prolactinoma (a tumour of the pituitary gland),
• have uncorrected levels of potassium, magnesium, or calcium in your blood,
• have cardiac disease (e.g., heart failure),
• have QT prolongation (a type of irregular heartbeat),
• have moderate or severe liver impairment.

Stop taking Domperidone tablets and see your doctor or go to a hospital right away if you:

• get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing. You could also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction to Domperidone tablets.
• notice uncontrolled movements. These include irregular eye movements, unusual movements of the tongue, and abnormal posture such as a twisted neck, trembling and muscle stiffness. This is more likely to happen in children. These symptoms should stop once you stop taking Domperidone tablets.
• have a very fast or unusual heartbeat. This could be a sign of a life-threatening heart problem.

Can Other Medicines Affect Motilium?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to make sure that the combination is safe.

Domperidone may speed up the of absorption of certain medicines from the gut, for example paracetamol. This effect can be useful in migraine.

Domperidone may oppose the prolactin-reducing effect of bromocriptine and cabergoline.

The following medicines may reduce the breakdown of domperidone by the liver. This could increase the amount of domperidone in the bloodstream and hence increase the risk of its side effects. There may also be an increased risk of irregular heartbeats if these medicines are used together. Domperidone should not be used in people taking any of these:

• the azole antifungals itraconazole, ketoconazole or voriconazole,
• the macrolide antibiotics clarithromycin, erythromycin or telithromycin,
• protease inhibitors for HIV infection such as ritonavir, indinavir, nelfinavir, saquinavir,
• telaprevir or boceprevir for hepatitis C.

There may be an increased chance of an abnormal heart rhythm, seen as a 'prolonged QT interval' on an ECG, if domperidone is taken in combination with other medicines that can have this side effect, such as those listed below. Domperidone should not be used with people taking any of these:

• anti-arrhythmic medicines to treat abnormal heart rhythms, eg amiodarone, procainamide, quinidine, disopyramide, dronedarone, sotalol,
• certain antidepressants, eg citalopram, escitalopram, clomipramine,
• the antihistamines terfenadine or mizolastine,
• certain antimalarials, eg halofantrine, lumefantrine,
• certain antipsychotics, eg amisulpride, thioridazine, chlorpromazine, sertindole, haloperidol, zuclopenthixol, sulpiride, droperidol,
• arsenic trioxide,
• artemether,
• bosutinib,
• cisapride,
• delamanid,
• dolasetron,
• methadone,
• moxifloxacin,
• pentamidine,
• prucalopride,
• quinine,
• ranolazine,
• tolterodine,
• toremifene,
• vandetanib,
• vardenafil,
• voriconazole.

There may also be an increased risk of a 'prolonged QT interval' if medicines that can alter the levels of salts such as potassium or magnesium in the blood, such as the following, are taken in combination with domperidone:

• amphotericin,
• beta agonists - such as salbutamol,
• corticosteroids - such as prednisolone,
• diuretics - such as furosemide,
• theophylline.

The following medicines may oppose the stimulating effect of domperidone on the gut and so is likely to make it less effective:

• antimuscarinic medicines - such as antispasmodics (e.g. atropine, hyoscine, propantheline), medicines for urinary incontinence (e.g. oxybutynin, flavoxate, tolterodine, propiverine, trospium), or antimuscarinics for Parkinson's (e.g. procyclidine, trihexyphenidyl, orphenadrine),
• strong opioid painkillers, e.g. morphine, codeine.

What about driving and using machinery?

You may feel sleepy, confused or have less control over your movements while taking Domperidone tablets. if this happens, do not drive or use any tools or machines.